ELMO3 Gene Summary [Human]

The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
ELMO3
Official Name
engulfment and cell motility 3 [Source:HGNC Symbol;Acc:HGNC:17289]
Ensembl ID
ENSG00000102890
Bio databases IDs NCBI: 79767 Ensembl: ENSG00000102890
Aliases engulfment and cell motility 3
Synonyms 9930107J06, CED-12, engulfment and cell motility 3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELMO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ELMO, armadillo-like helical domain
  • ELMO/CED-12 family
  • protein binding
  • Pleckstrin homology-like domain
  • Pleckstrin homology domain

Pathways

Biological processes and signaling networks where the ELMO3 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • IL2
  • 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • methylnitrosourea
regulates

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ELMO3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell motility
  • apoptotic process
  • phagocytosis
  • actin filament organization

Cellular Component

Where in the cell the gene product is active
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • SH3 domain binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.