CD244
CD244 Gene Summary
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | CD244 |
| Official Name | CD244 molecule [Source:HGNC Symbol;Acc:HGNC:18171] |
| Ensembl ID | ENSG00000122223 |
| Bio databases IDs | |
| Aliases | CD244 molecule |
| Synonyms | 2B4,C9.1,Cd244a,CD244 antigen,CD244 molecule,CD244 molecule A,F730046O15Rik,h2B4,Ly90,NAIL,NKR2B4,NMRK,SLAMF4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- soluble domain
- MHC class I protein binding
- signaling receptor activity
- immunoglobulin domain
- protein binding
- V domain
- cytoplasmic domain
- cytosolic tail domain
- tyrosine phosphorylation site
- Immunoglobulin V-set domain
- transmembrane receptor
- immunoreceptor tyrosine switch motif
- tyrosine-based motif
Pathways
Biological processes and signaling networks where the CD244 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FYN
- SH2D1B
- PTPN11
- CD48
- PDXDC1
- HEATR6
- ST7
- Sh2d1b1
- ELMO3
- SH2D1A
disease
- susceptibility to rheumatoid arthritis
- diabetic nephropathy
- cutaneous melanoma
- cutaneous melanoma cancer
- Crohn disease
- intrauterine growth retardation
- chronic lymphocytic leukemia
regulated by
- IL2
- B lymphocytes
- pervanadate
- STAT3
- CD48
- wortmannin
- tretinoin
- 5-hydroxytryptamine
- CD244
- IL1B
regulates
- TNF
- NFkB (complex)
- p38 MAPK
- EGR1
- CCL5
- ERK
- IL4
- Ca2+
- ERK1/2
- CSF2
role in cell
- expression in
- quantity
- proliferation
- activation
- activation in
- production in
- activity
- phosphorylation in
- binding in
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CD244 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- natural killer cell activation involved in immune response
- positive regulation of interleukin-8 production
- positive regulation of granzyme B production
- signal transduction
- innate immune response
- positive regulation of interferon-gamma production
- adaptive immune response
- positive regulation of inositol phosphate biosynthetic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- MHC class I protein binding