TMEM147 Gene Summary [Human]
Enables ribosome binding activity. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMEM147 |
| Official Name | transmembrane protein 147 [Source:HGNC Symbol;Acc:HGNC:30414] |
| Ensembl ID | ENSG00000105677 |
| Bio databases IDs | |
| Aliases | transmembrane protein 147 |
| Synonyms | 2010004E11Rik, 5033425B17Rik, NEDFLPH, NIFIE14, RGD1304706, transmembrane protein 147 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM147 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribosome binding
- protein binding
- Predicted membrane protein (DUF2053)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- hepatocellular carcinoma
- organismal death
- neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-Pelger-Huet anomaly
- gallstone
- liver cancer
- epithelial cancer
- cholelithiasis
- biliary atresia
regulated by
- Ebna2
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- cell viability
- invasion by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM147 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to nuclear inner membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding