Tmem147 Gene Summary [Mouse]
Predicted to enable ribosome binding activity. Predicted to be involved in multi-pass transmembrane protein insertion into ER membrane and protein localization to nuclear inner membrane. Predicted to be located in nuclear membrane and plasma membrane. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in genitourinary system. Orthologous to human TMEM147 (transmembrane protein 147). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tmem147 |
| Official Name | transmembrane protein 147 [Source:MGI Symbol;Acc:MGI:1915011] |
| Ensembl ID | ENSMUSG00000006315 |
| Bio databases IDs | |
| Aliases | transmembrane protein 147 |
| Synonyms | 2010004E11Rik, 5033425B17Rik, NEDFLPH, NIFIE14, RGD1304706, transmembrane protein 147 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem147 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribosome binding
- protein binding
- Predicted membrane protein (DUF2053)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- hepatocellular carcinoma
- organismal death
- neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-Pelger-Huet anomaly
- gallstone
- liver cancer
- epithelial cancer
- cholelithiasis
- biliary atresia
regulated by
- Ebna2
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- cell viability
- invasion by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem147 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to nuclear inner membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding