MPP6 Gene Summary [Human]
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | MPP6 |
| Official Name | membrane palmitoylated protein 6 [Source:HGNC Symbol;Acc:HGNC:18167] |
| Ensembl ID | ENSG00000105926 |
| Bio databases IDs | |
| Aliases | membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK p55 family member |
| Synonyms | FIN15, MPP6, P55t, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, VAM-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MPP6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- guanylate kinase
- Domain present in PSD-95, Dlg, and ZO-1/2
- NK
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- L27 domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the MPP6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- post-traumatic stress disorder
- gout
- major depression
- acute myeloid leukemia
- neuroticism
- bipolar disorder
- pervasive developmental disorder
- colorectal cancer
- attention deficit hyperactivity disorder
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- cell-cell contacts
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MPP6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- extracellular vesicular exosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding