EPHA2
EPHA2 Gene Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | EPHA2 |
| Official Name | EPH receptor A2 [Source:HGNC Symbol;Acc:HGNC:3386] |
| Ensembl ID | ENSG00000142627 |
| Bio databases IDs | |
| Aliases | EPH receptor A2 |
| Synonyms | ARCC2,CTPA,CTPP,CTPP1,CTRCT6,ECK,Epha2 predicted,EPH receptor A2,Myk2,Sek-2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- globular domain
- SAM domain
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- Sterile alpha motif
- cytoplasmic domain
- ligand-binding domain
- SAM domain (Sterile alpha motif)
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- Ligand Binding Domain of Ephrin Receptors
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- Purple acid Phosphatase, N-terminal domain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- FN3
- transmembrane domain
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the EPHA2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FGFR2
- PDGFRA
- EGFR
- FGFR3
- FGFR1
- STIM1
- DNAJC5
- SLC30A1
- VANGL1
- MPZL1
disease
- unresectable gastrointestinal stromal tumor
- gastrointestinal stromal tumor
- metastatic gastrointestinal stromal tumor
- breast cancer
- neoplasia
- epithelial neoplasia
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
regulated by
- IL1B
- diethylstilbestrol
- TP73
- KRAS
- TNF
- EFNA1
- 5-fluorouracil
- EGF
- GRN
- human herpesvirus 8
regulates
- MTOR
- IL1B
- cholesterol
- FOS
- IL13
- IL5
- SREBF1
- IL4
- cyclic AMP
- DUSP1
role in cell
- formation
- expression in
- proliferation
- migration
- chemotaxis
- number
- paclitaxel sensitivity
- survival
- morphology
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- microvesicles
- cellular membrane
- focal adhesions
- intercellular junctions
- cell-cell contacts
- lateral cell surfaces
- membrane ruffles
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the EPHA2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- viral entry into host cell
- neural tube development
- negative regulation of angiogenesis
- lens fiber cell morphogenesis
- response to growth factor stimulus
- multicellular organismal development
- regulation of angiogenesis
- cell adhesion
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- vasculogenesis
- branching involved in mammary gland duct morphogenesis
- cell chemotaxis
- axial mesoderm formation
- inflammatory response
- skeletal system development
- osteoblast differentiation
- mammary gland epithelial cell proliferation
- positive regulation of kinase activity
- cell migration
- defense response to Gram-positive bacterium
- regulation of lamellipodium assembly
- notochord cell development
- bone remodeling
- neuron differentiation
- negative regulation of chemokine production
- transmembrane receptor protein tyrosine kinase signaling pathway
- DNA damage response, signal transduction resulting in induction of apoptosis
- regulation of blood vessel endothelial cell migration
- osteoclast differentiation
- cell motility
- regulation of cell adhesion mediated by integrin
- keratinocyte differentiation
- regulation of ERK1 and ERK2 cascade
- cAMP metabolic process
- ephrin receptor signaling pathway
- notochord formation
- protein localization in plasma membrane
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- occluding junction
- focal adhesion
- ruffle membrane
- leading edge membrane
- receptor complex
- plasma membrane
- lamellipodium membrane
- lamellipodium
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- growth factor binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- cadherin binding
- viral receptor activity
- ephrin receptor activity