Mpp6 Gene Summary [Mouse]
Predicted to enable guanylate kinase activity. Predicted to be involved in GDP metabolic process and GMP metabolic process. Located in plasma membrane. Is expressed in heart. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mpp6 |
| Official Name | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) [Source:MGI Symbol;Acc:MGI:1927340] |
| Ensembl ID | ENSMUSG00000038388 |
| Bio databases IDs | |
| Aliases | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) |
| Synonyms | FIN15, MPP6, P55t, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, VAM-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mpp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- guanylate kinase
- Domain present in PSD-95, Dlg, and ZO-1/2
- NK
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- L27 domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Mpp6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- post-traumatic stress disorder
- gout
- major depression
- acute myeloid leukemia
- neuroticism
- bipolar disorder
- pervasive developmental disorder
- colorectal cancer
- attention deficit hyperactivity disorder
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- cell-cell contacts
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mpp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- extracellular vesicular exosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding