MINDY3 Gene Summary [Human]
The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | MINDY3 |
| Official Name | MINDY lysine 48 deubiquitinase 3 [Source:HGNC Symbol;Acc:HGNC:23578] |
| Ensembl ID | ENSG00000148481 |
| Bio databases IDs | |
| Aliases | MINDY lysine 48 deubiquitinase 3, caspase recruitment domain containing pro-apoptotic protein, CARD-containing protein |
| Synonyms | 1810041E18Rik, 2310047O13RIK, 5830410F13Rik, C10orf97, CARP, DERP5, FAM188A, MINDY lysine 48 deubiquitinase 3, MST126, MSTP126, my042, RGD1309605 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MINDY3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin-specific protease
- enzyme
- protein binding
- Deubiquitinating enzyme MINDY-3/4, conserved domain
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MINDY3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding