NOBOX Gene Summary [Human]
This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5.[provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | NOBOX |
| Official Name | NOBOX oogenesis homeobox [Source:HGNC Symbol;Acc:HGNC:22448] |
| Ensembl ID | ENSG00000106410 |
| Bio databases IDs | |
| Aliases | NOBOX oogenesis homeobox, newborn ovary homeobox-encoding gene |
| Synonyms | NOBOX oogenesis homeobox, OG-2, OG2X, POF5, RGD1563929, TCAG 12042 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOBOX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
disease
- premature ovarian failure type 5
- familial premature ovarian failure
- premature ovarian failure
role in cell
- number
- abnormal morphology
- degeneration
- lack
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOBOX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity