Nobox Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within ovarian follicle development. Located in cytoplasm. Is expressed in several structures, including eye; genitourinary system; heart; liver; and musculoskeletal system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 5. Orthologous to human NOBOX (NOBOX oogenesis homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nobox |
| Official Name | NOBOX oogenesis homeobox [Source:MGI Symbol;Acc:MGI:108011] |
| Ensembl ID | ENSMUSG00000029736 |
| Bio databases IDs | |
| Aliases | NOBOX oogenesis homeobox |
| Synonyms | NOBOX oogenesis homeobox, OG-2, OG2X, POF5, RGD1563929, TCAG 12042 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nobox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- premature ovarian failure type 5
- familial premature ovarian failure
- premature ovarian failure
regulated by
role in cell
- number
- abnormal morphology
- degeneration
- lack
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nobox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity