RCVRN Gene Summary [Human]

This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
RCVRN
Official Name
recoverin [Source:HGNC Symbol;Acc:HGNC:9937]
Ensembl ID
ENSG00000109047
Bio databases IDs NCBI: 5957 Ensembl: ENSG00000109047
Aliases recoverin
Synonyms CAR, RCV1, RECOVERIN, S-modulin
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RCVRN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • EF-Hand
  • EF-hand, calcium binding motif
  • EF-hand domain
  • calcium sensitive guanylate cyclase activator
  • EF-hand domain pair
  • EF hand
  • calcium ion binding
  • EFh

Pathways

Biological processes and signaling networks where the RCVRN gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • acute myeloid leukemia
  • spinocerebellar ataxia type 7
regulated by
regulates
role in cell
  • proliferation
  • decay in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • endosomes
  • lysosome
  • synapse
  • photoreceptor outer segments
  • photoreceptor inner segments
  • membrane processes
  • perikaryon
  • dendrites
  • rod inner segments
  • cone inner segments

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human RCVRN gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • signal transduction
  • regulation of calcium ion transport
  • visual perception
  • phototransduction

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • membrane
  • photoreceptor inner segment
  • perikaryon
  • photoreceptor outer segment

Molecular Function

What the gene product does at the molecular level
  • calcium ion binding
  • calcium sensitive guanylate cyclase activator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.