SNX25 Gene Summary [Human]
Predicted to enable type I transforming growth factor beta receptor binding activity. Involved in negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; and receptor catabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SNX25 |
| Official Name | sorting nexin 25 [Source:HGNC Symbol;Acc:HGNC:21883] |
| Ensembl ID | ENSG00000109762 |
| Bio databases IDs | |
| Aliases | sorting nexin 25 |
| Synonyms | AI661919, Gm1699, Gm173, LRP2BP-AS1, MSTP043, RP11 714G181, SBBI31, sorting nexin 25 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNX25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- transforming growth factor-beta receptor binding
- PXA domain
- Sorting nexin C terminal
- Regulator of G protein signaling (RGS) domain superfamily
- The Phox Homology domain, a phosphoinositide binding module
- PX domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNX25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- receptor catabolic process
- protein transport
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endosome
- intracellular membrane-bounded organelle
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol binding