TSPAN5

TSPAN5 Gene Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Details

Type
Nonsense Mediated Decay
Official Symbol
TSPAN5
Official Name
tetraspanin 5 [Source:HGNC Symbol;Acc:HGNC:17753]
Ensembl ID
ENSG00000168785
Bio databases IDs NCBI: 10098 Ensembl: ENSG00000168785
Aliases tetraspanin 5
Synonyms
2810455A09Rik,4930505M03Rik,NET-4,Tetraspanin 5,TM4SF9
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • tetraspanin_LEL
  • enzyme binding
  • protein binding
  • Tetraspanin family

Pathways

Biological processes and signaling networks where the TSPAN5 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • GPR89A
  • B4GALT1
  • TRIM25
  • NAT8L
  • TMEM186
  • ADAM10
  • GHDC
  • ZDHHC6
  • SOAT1
  • AGPAT3
disease
  • idiopathic scoliosis
  • organismal death
  • ischemic stroke
  • insomnia
  • renal cell carcinoma
  • renal cell cancer
  • stroke
  • dementia
  • ototoxicity
regulated by
  • beta-estradiol
  • TGFBR2
  • TNFSF11
  • WT1
  • IL4
  • STAT4
  • FTO
  • CST5
  • FARSA
  • OGA
regulates
  • MHC I (family)
  • HLA-A
  • CDH5
role in cell
  • proliferation
  • migration
  • expression in
  • invasion by
  • colony formation by
  • clustering in
  • adhesion
  • transmigration
  • osteoclastogenesis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • actin cytoskeleton
  • Endoplasmic Reticulum
  • endoplasmic reticulum lumen
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the TSPAN5 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • regulation of membrane protein ectodomain proteolysis
  • protein maturation
  • positive regulation of Notch signaling pathway
  • protein localization in plasma membrane

CELLULAR COMPONENT

Where in the cell the gene product is active
  • endoplasmic reticulum lumen
  • actin cytoskeleton
  • plasma membrane
  • nucleoplasm

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • protein binding
  • enzyme binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.