CRTAM Gene Summary [Human]
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | CRTAM |
| Official Name | cytotoxic and regulatory T cell molecule [Source:HGNC Symbol;Acc:HGNC:24313] |
| Ensembl ID | ENSG00000109943 |
| Bio databases IDs | |
| Aliases | cytotoxic and regulatory T cell molecule, class I MHC restricted T cell associated molecule |
| Synonyms | CD355, cytotoxic and regulatory T cell molecule |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRTAM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ophthalmic disorder
- insulin-dependent diabetes mellitus
- prostate cancer
- dementia
- early missed abortion
- infection by bacteria
role in cell
- proliferation
- expression in
- differentiation
- production in
- activation
- number
- function
- cell polarity formation
- recognition
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- immunological synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRTAM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of CD8-positive, alpha-beta T cell activation
- heterophilic cell-cell adhesion
- cell recognition
- negative regulation of activated T cell proliferation
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- lymphocyte migration into lymphoid organs
- positive regulation of natural killer cell mediated cytotoxicity
- detection of tumor cell
- regulation of T cell differentiation
- establishment of T cell polarity
- positive regulation of interferon-gamma production
- T cell mediated cytotoxicity
- detection of stimulus
- positive regulation of cytokine production
- regulation of T cell activation
- activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- receptor binding