Crtam Gene Summary [Rat]
Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including detection of tumor cell; establishment of T cell polarity; and regulation of T cell activation. Predicted to be located in immunological synapse. Predicted to be active in plasma membrane. Orthologous to human CRTAM (cytotoxic and regulatory T cell molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crtam |
| Official Name | cytotoxic and regulatory T cell molecule [Source:RGD Symbol;Acc:1304602] |
| Ensembl ID | ENSRNOG00000008153 |
| Bio databases IDs | |
| Aliases | cytotoxic and regulatory T cell molecule |
| Synonyms | CD355, cytotoxic and regulatory T cell molecule |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crtam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ophthalmic disorder
- insulin-dependent diabetes mellitus
- prostate cancer
- dementia
- early missed abortion
- infection by bacteria
role in cell
- proliferation
- expression in
- differentiation
- production in
- activation
- number
- function
- cell polarity formation
- recognition
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- immunological synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crtam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of CD8-positive, alpha-beta T cell activation
- heterophilic cell-cell adhesion
- cell recognition
- negative regulation of activated T cell proliferation
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- lymphocyte migration into lymphoid organs
- positive regulation of natural killer cell mediated cytotoxicity
- detection of tumor cell
- regulation of T cell differentiation
- establishment of T cell polarity
- positive regulation of interferon-gamma production
- T cell mediated cytotoxicity
- detection of stimulus
- positive regulation of cytokine production
- regulation of T cell activation
- activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- receptor binding