CADM1 Gene Summary [Human]
Enables signaling receptor binding activity. Involved in several processes, including cell recognition; positive regulation of cytokine production; and susceptibility to natural killer cell mediated cytotoxicity. Located in plasma membrane. Implicated in breast carcinoma and prostate cancer. Biomarker of cervix uteri carcinoma in situ. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CADM1 |
| Official Name | cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5951] |
| Ensembl ID | ENSG00000182985 |
| Bio databases IDs | |
| Aliases | cell adhesion molecule 1, nectin-like 2 |
| Synonyms | 2900073G06Rik, 3100001I08Rik, BL2, cell adhesion molecule 1, IGSF4, IGSF4A, NECL2, RA175, RA175A, RA175B, RA175C, RA175N, SgIGSF, ST17, sTSLC-1, SYNCAM, SynCAM1, TSLC-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CADM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FERM domain binding motif
- immunoglobulin domain
- ectodomain
- cell adhesion molecule binding
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- PDZ-domain binding
- ERM binding domain
- putative band 4.1 homologues' binding motif
- CD19_double_Ig
- cytoplasmic domain
- Immunoglobulin like
- transmembrane domain
- intracellular domain
- protein homodimerization
- cytosolic tail domain
- PDZ binding motif
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- teratozoospermia
- asthenozoospermia
- oligozoospermia
- metabolic syndrome X
- bladder cancer
- celiac disease
- osteosarcoma
- osteosarcomagenesis
- overnutrition
- obesity
role in cell
- binding in
- apoptosis
- expression in
- activation in
- cell viability
- quantity
- size
- growth
- number
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- glutaminergic synapse
- spot-like adhesion site
- line-like adhesion site
- hemidesmosome-like structure
- cell-matrix contacts
- cell surface
- cellular membrane
- Nucleus
- intercellular junctions
- immunological synapses
- cell-cell contacts
- lateral cell surfaces
- apical cell surfaces
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- lateral plasma membrane
- nuclear envelope
- residual bodies
- synaptic vesicles
- growth cone
- nerve ending
- internodes
- synapse
- central supramolecular activation cluster
- Schmidt-Lanterman incisures
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CADM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- heterophilic cell-cell adhesion
- cell recognition
- homophilic cell adhesion
- positive regulation of natural killer cell mediated cytotoxicity
- susceptibility to natural killer cell mediated cytotoxicity
- negative regulation of protein phosphorylation
- liver development
- apoptotic process
- cell differentiation
- T cell mediated cytotoxicity
- detection of stimulus
- positive regulation of cytokine production
- activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- cell-cell junction
- synapse
- basolateral plasma membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- cell adhesion molecule binding
- PDZ domain binding
- receptor binding