UPK2 Gene Summary [Human]
This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
Details
| Type | Processed Transcript |
| Official Symbol | UPK2 |
| Official Name | uroplakin 2 [Source:HGNC Symbol;Acc:HGNC:12579] |
| Ensembl ID | ENSG00000110375 |
| Bio databases IDs | |
| Aliases | uroplakin 2, uroplakin II, uroplakin-2 |
| Synonyms | AW491716, LOC683386, UP2, UPII, uroplakin 2, Uroplakin II |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UPK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Uroplakin IIIb, IIIa and II
- protein binding
- Uroplakin II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hydronephrosis
- growth failure
- polyuria
- vesicoureteral reflux
- urothelial carcinoma
- urothelial cancer
role in cell
- size
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UPK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding