Upk2 Gene Summary [Mouse]
Predicted to be involved in epithelial cell differentiation. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in Meckel's cartilage; bladder; and skeleton. Orthologous to human UPK2 (uroplakin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upk2 |
| Official Name | uroplakin 2 [Source:MGI Symbol;Acc:MGI:98913] |
| Ensembl ID | ENSMUSG00000041523 |
| Bio databases IDs | |
| Aliases | uroplakin 2 |
| Synonyms | AW491716, LOC683386, UP2, UPII, uroplakin 2, Uroplakin II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Upk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Uroplakin IIIb, IIIa and II
- protein binding
- Uroplakin II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hydronephrosis
- growth failure
- polyuria
- vesicoureteral reflux
- urothelial carcinoma
- urothelial cancer
regulates
- K+
- UPK1B
- Na+
- uric acid
- creatinine
- chloride
- blood urea nitrogen
role in cell
- size
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Upk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding