CALCA Gene Summary [Human]
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Details
| Type | Protein Coding |
| Official Symbol | CALCA |
| Official Name | calcitonin related polypeptide alpha [Source:HGNC Symbol;Acc:HGNC:1437] |
| Ensembl ID | ENSG00000110680 |
| Bio databases IDs | |
| Aliases | calcitonin related polypeptide alpha, calcitonin |
| Synonyms | CA, Cal1, CAL6, Calc, CALC1, calcitonin, calcitonin/calcitonin-related polypeptide, alpha, calcitonin/calcitonin-related polypeptide, α, calcitonin-related polypeptide alpha, calcitonin-related polypeptide α, CGRP, CGRP-1, Cgrp α, CT, CT/CGRP, Ctn, KC, PCT, Procalcitonin, RATCAL6, α-calcitonin gene-related peptide, α Cgrp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CALCA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcitonin / CGRP / IAPP family
- binding protein
- G-protein-coupled receptor binding
- calcitonin
- hormone
- protein binding
- receptor binding
- neuropeptide hormone
- identical protein binding
Pathways
Biological processes and signaling networks where the CALCA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- migraines
- anorexia
- weight gain
- sepsis
- obesity
- systemic sclerosis-associated pulmonary arterial hypertension
- headache
- edema
- migraine without aura
role in cell
- activity
- proliferation
- differentiation
- apoptosis
- expression in
- production in
- quantity
- activation
- activation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- peptidergic fiber
- intracellular structures
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- vesicles
- granules
- neurites
- synapse
- dense-core vesicles
- secretory granules
- perikaryon
- axons
- axon terminals
- plasma
- C fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CALCA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- feeding behavior
- endothelial cell migration
- vasodilation
- protein phosphorylation
- leukocyte cell-cell adhesion
- negative regulation of smooth muscle contraction
- response to pain
- response to heat
- inflammatory response
- vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
- negative regulation of transcription, DNA-dependent
- smooth muscle contraction
- ossification
- positive regulation of macrophage differentiation
- vasculature development
- negative regulation of osteoclast differentiation
- activation of protein kinase activity
- cellular response to tumor necrosis factor
- activation of adenylate cyclase activity
- cell-cell signaling
- cytosolic calcium ion homeostasis
- G-protein coupled receptor internalization
- phospholipase C-activating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- negative regulation of bone resorption
- regulation of blood pressure
- embryo implantation
- elevation of cytosolic calcium ion concentration
- positive regulation of interleukin-8 production
- neuropeptide signaling pathway
- monocyte chemotaxis
- negative regulation of calcium ion transport into cytosol
- endothelial cell proliferation
- positive regulation of interleukin-1 alpha production
- negative regulation of ossification
- receptor internalization
- detection of temperature stimulus involved in sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- terminal button
- neuronal cell body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcitonin receptor binding
- hormone activity
- receptor binding