RAMP1 Gene Summary [Human]
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | RAMP1 |
| Official Name | receptor activity modifying protein 1 [Source:HGNC Symbol;Acc:HGNC:9843] |
| Ensembl ID | ENSG00000132329 |
| Bio databases IDs | |
| Aliases | receptor activity modifying protein 1 |
| Synonyms | 9130218E19RIK, receptor activity modifying protein 1, Receptor (calcitonin) activity modifying protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAMP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- extracellular domain
- calcitonin gene-related polypeptide receptor
- cytoplasmic domain
- Receptor activity modifying family
- transmembrane domain
- intracellular domain
- tail domain
- protein binding
- polypeptide hormone binding
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- obesity
- insulin-dependent diabetes mellitus
- organismal death
- contact hypersensitivity
- hypoglycemia
- autosomal dominant polycystic kidney disease
- uterine serous papillary cancer
role in cell
- growth
- production in
- binding
- activation in
- proliferation
- migration
- sphere formation by
- internalization in
- mobilization
- receptor-mediated endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- synaptic membrane
- acrosome
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAMP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- angiogenesis
- calcium ion transport
- protein transport
- cellular response to hormone stimulus
- positive regulation of protein glycosylation
- regulation of G-protein coupled receptor protein signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- intracellular protein transport
- receptor internalization
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- calcitonin gene-related polypeptide receptor activity