MAGOHB Gene Summary [Human]
Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type precatalytic spliceosome; and exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MAGOHB |
| Official Name | mago homolog B, exon junction complex subunit [Source:HGNC Symbol;Acc:HGNC:25504] |
| Ensembl ID | ENSG00000111196 |
| Bio databases IDs | |
| Aliases | mago homolog B, exon junction complex subunit |
| Synonyms | 2010012C16Rik, LOC684298, Mago, Magoh, mago homolog B, exon junction complex core component, mago homolog B, exon junction complex subunit, Magoh-rs1, MGN2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAGOHB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mago nashi proteins, integral members of the exon junction complex
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAGOHB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA splicing
- regulation of mRNA processing
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- catalytic step 2 spliceosome
- U2-type catalytic step 1 spliceosome
- cytosol
- U2-type precatalytic spliceosome
- neuronal cell body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding