SLC22A2 Gene Summary [Human]
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SLC22A2 |
| Official Name | solute carrier family 22 member 2 [Source:HGNC Symbol;Acc:HGNC:10966] |
| Ensembl ID | ENSG00000112499 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 2, organic cation transporter 2 |
| Synonyms | mOCT2, OCT2, OCT2r, Orct2, rOCT2, solute carrier family 22 member 2, solute carrier family 22 (organic cation transporter), member 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC22A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- efflux permease
- pyrimidine nucleoside transporter
- MFS transporter, sugar porter (SP) family
- Multidrug resistance protein
- Major Facilitator Superfamily
- phosphate:H+ symporter
- monoamine transporter
- spermidine transporter
- thiamin transporter
- toxin transporter
- drug resistance transporter, Bcr/CflA subfamily
- putrescine transporter
- metabolite-proton symporter
- L-amino acid transporter
- choline transporter
- neurotransmitter transporter
- basic amino acid transporter
- organic anion transporter
- prostaglandin transporter
- steroid binding
- amine/polyamine transporter
- organic cation transporter
- Sugar (and other) transporter
- xenobiotic transporter
- acetylcholine transporter
- cation transport protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- prostate cancer
- kidney disease
- abdominal aortic aneurysm
- chronic kidney disease
- renal failure
- coronary artery disease
- major depression
- anhedonia
regulated by
- D-glucose
- sparteine
- torin1
- pifithrin alpha
- guanabenz
- LIPE
- olanzapine
- rabeprazole
- J-774A.1 cells
- cisplatin
regulates
- AKT
- metformin
- prostaglandin
- dopamine
- chloroquine
- Bamet-UD2
- 4-(4-dimethylaminostyryl)-N-methylpyridinium
- neurotransmitter
- diaminneplatinum(II)-chlorocholylglycinate
- cisplatin
role in cell
- apoptosis
- expression in
- production in
- accumulation in
- uptake by
- cytotoxic reaction
- transport in
- survival
- cell death
- transcellular transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- cellular membrane
- apical membrane
- presynaptic membrane
- basolateral membrane
- basal membrane
- synapse
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC22A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- norepinephrine transport
- quaternary ammonium group transport
- dopamine transport
- organic cation transport
- choline transport
- acetylcholine transport
- histamine transport
- norepinephrine uptake
- neurotransmitter transport
- epinephrine transport
- cation transport
- serotonin transport
- spermidine transport
- putrescine transport
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- thiamine transmembrane transport
- body fluid secretion
- serotonin uptake
- purine-containing compound transmembrane transport
- positive regulation of gene expression
- xenobiotic transport
- amine transport
- histamine uptake
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- extracellular vesicular exosome
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- putrescine transmembrane transporter activity
- pyrimidine nucleoside transmembrane transporter activity
- xenobiotic transporter activity
- thiamine transmembrane transporter activity
- L-amino acid transmembrane transporter activity
- organic cation transmembrane transporter activity
- quaternary ammonium group transmembrane transporter activity
- efflux transmembrane transporter activity
- prostaglandin transmembrane transporter activity
- choline transmembrane transporter activity
- amine transmembrane transporter activity
- acetylcholine transmembrane transporter activity
- monoamine transmembrane transporter activity
- organic anion transmembrane transporter activity
- neurotransmitter transporter activity
- spermidine transmembrane transporter activity
- toxin transporter activity