LIPE
LIPE Gene Summary
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LIPE |
| Official Name | lipase E, hormone sensitive type [Source:HGNC Symbol;Acc:HGNC:6621] |
| Ensembl ID | ENSG00000079435 |
| Bio databases IDs | |
| Aliases | lipase E, hormone sensitive type |
| Synonyms | 4933403G17RIK,AOMS4,Cholesteryl Ester Hydrolase,FPLD6,Hormone-sensitive Lipase,HSL,LHS,lipase E, hormone sensitive type,lipase, hormone sensitive,LOC100503639,LOC100862213,Neutral ce hydrolase,REH |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- protein kinase binding
- sterol esterase
- alpha/beta hydrolases
- catalytic domain
- enzyme
- protein binding
- phosphorylation site
- triacylglycerol lipase
- rRNA primary transcript binding
- alpha/beta hydrolase fold
- Hormone-sensitive lipase (HSL) N-terminus
- acylglycerol lipase
- lipase
- AMPK phosphorylation site
- serine hydrolase
- retinyl-palmitate esterase
- Pka phosphorylation site
- ester bond hydrolase
Pathways
Biological processes and signaling networks where the LIPE gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FABP4
- STAR
- PLIN5
- PLIN1
- SOX5
- LIPE
- FABP9
- PLIN2
- ARF6
- NR1H
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- fibrosis
- adjuvant arthritis
- metastasis
- advanced cancer
- cervical cancer
- obesity
- pancreatic epithelial cancer
regulated by
- TNF
- ethanol
- progesterone
- curcumin
- mitotane
- Immunoglobulin
- epinephrine
- IL1B
- D-glucose
- PRKN
regulates
- TNF
- IL6
- D-glucose
- adenosine triphosphate
- AKT1
- glycerol
- CA2
- IL1B
- fatty acid
- MRC1
role in cell
- expression in
- synthesis in
- number
- phosphorylation in
- generation in
- invasion by
- cell death
- loss
- glycolysis in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- membrane fraction
- Extracellular Space
- cellular membrane
- Nucleus
- Mitochondria
- lipid droplets
- cytosol
- caveolae
- residual bodies
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the LIPE gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- diacylglycerol catabolic process
- ether lipid metabolic process
- lipid catabolic process
- retinol metabolic process
- cholesterol metabolic process
- triglyceride catabolic process
- protein phosphorylation
CELLULAR COMPONENT
Where in the cell the gene product is active
- lipid particle
- caveola
- membrane
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- acylglycerol lipase activity
- protein binding
- all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
- retinyl-palmitate esterase activity
- triglyceride lipase activity
- sterol esterase activity
- hormone-sensitive lipase activity