NEK6 Gene Summary [Human]
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | NEK6 |
| Official Name | NIMA related kinase 6 [Source:HGNC Symbol;Acc:HGNC:7749] |
| Ensembl ID | ENSG00000119408 |
| Bio databases IDs | |
| Aliases | NIMA related kinase 6, putative serine-threonine protein kinase |
| Synonyms | 1300007C09Rik, NIMA (never in mitosis gene a)-related expressed kinase 6, NIMA-related kinase 6, SID6-1512 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEK6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- transcription factor binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- activation loop
- kinesin binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal adenocarcinoma
- tonsillitis
- non-Hodgkin lymphoma
- rhinitis
- cancer
- epithelial cancer
- osteosarcoma
- breast cancer
- glioblastoma
- glioblastoma cancer
role in cell
- expression in
- proliferation
- migration
- formation
- assembly
- apoptosis
- morphology
- phosphorylation in
- invasion by
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- microtubules
- midbody
- cytosol
- nucleoplasm
- spindle pole
- central spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEK6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- mitotic nuclear envelope disassembly
- mitotic spindle organization
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- chromosome segregation
- protein autophosphorylation
- protein phosphorylation
- regulation of mitotic cell cycle
- cell division
- spindle assembly
- apoptotic process
- peptidyl-serine phosphorylation
- regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- nuclear speck
- centriolar satellite
- spindle pole
- cytosol
- macromolecular complex
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- magnesium ion binding
- protein kinase binding
- ATP binding
- ubiquitin protein ligase binding
- protein binding
- kinesin binding
- protein serine/threonine kinase activity