HHLA2 Gene Summary [Human]
This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | HHLA2 |
| Official Name | HERV-H LTR-associating 2 [Source:HGNC Symbol;Acc:HGNC:4905] |
| Ensembl ID | ENSG00000114455 |
| Bio databases IDs | |
| Aliases | HERV-H LTR-associating 2 |
| Synonyms | B7-H5, B7-H7, B7y, HHLA2 member of B7 family |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HHLA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HHLA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell costimulation
- regulation of cytokine production
- positive regulation of cytokine production
- positive regulation of activated T cell proliferation
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding