AQP9 Gene Summary [Human]

The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Details

Type
Protein Coding
Official Symbol
AQP9
Official Name
aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643]
Ensembl ID
ENSG00000103569
Bio databases IDs NCBI: 366 Ensembl: ENSG00000103569
Aliases aquaporin 9
Synonyms 1700020I22RIK, aquaporin 9, HsT17287, SSC1, T17287
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AQP9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • purine transporter
  • channel/pore class transporter
  • MIP
  • glycerol channel
  • urea transporter
  • inorganic uptake permease
  • protein binding
  • polyol transporter
  • pyrimidine transporter
  • water channel
  • transporter
  • urea channel

Pathways

Biological processes and signaling networks where the AQP9 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • psoriasis
  • osteoarthritis
  • coronary artery disease
  • primary pulmonary hypertension
  • rheumatoid arthritis
  • colorectal cancer
  • ulcerative colitis
  • liver cancer
  • hepatitis B virus-related hepatocellular carcinoma
regulated by
regulates
  • D-glucose
  • CTNNB1
  • reactive oxygen species
  • SNAI1
  • water
  • glycerol
  • arsenic
  • purine base
  • carbamides
  • pyrimidine base
role in cell
  • chemotaxis
  • production in
  • growth
  • function
  • motility
  • urea permeability
  • glycerol permeability
  • roundness
  • polarization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • plasma membrane fraction
  • intracellular membrane-bounded organelle
  • cell borders
  • cellular membrane
  • basolateral cell surfaces
  • basolateral membrane
  • sinusoidal membrane
  • microvilli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human AQP9 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • response to pain
  • water transport
  • glycerol transport
  • pyrimidine-containing compound transmembrane transport
  • urea transmembrane transport
  • cellular response to cAMP
  • amine transport
  • pyrimidine base transport
  • canalicular bile acid transport
  • purine base transport

Cellular Component

Where in the cell the gene product is active
  • intracellular membrane-bounded organelle
  • basolateral plasma membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • glycerol channel activity
  • urea channel activity
  • pyrimidine base transmembrane transporter activity
  • water channel activity
  • purine base transmembrane transporter activity
  • urea transmembrane transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.