IGFBP2 Gene Summary [Human]
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | IGFBP2 |
| Official Name | insulin like growth factor binding protein 2 [Source:HGNC Symbol;Acc:HGNC:5471] |
| Ensembl ID | ENSG00000115457 |
| Bio databases IDs | |
| Aliases | insulin like growth factor binding protein 2 |
| Synonyms | BRL-BP, IBP-2, IGF-BP53, ILGFBPA, insulin-like growth factor binding protein 2, mIGFBP-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGFBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- TY
- RGD motif
- heparin binding domain
- insulin-like growth factor binding
- receptor inhibitor
- linker domain
- protein binding
- receptor binding
- Insulin-like growth factor binding protein
Pathways
Biological processes and signaling networks where the IGFBP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- major depression
- neoplasia
- obesity
- epithelial cancer
- cancer
- liver cancer
- metastasis
- HER2 negative hormone receptor negative breast cancer
- glioblastoma
role in cell
- formation
- growth
- expression in
- production in
- accumulation in
- differentiation
- binding
- cell death
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- perinuclear region
- Nucleus
- apical membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGFBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- female pregnancy
- response to nutrient
- response to xenobiotic stimulus
- regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of activated T cell proliferation
- response to mechanical stimulus
- negative regulation of canonical Wnt receptor signaling pathway
- response to retinoic acid
- response to glucocorticoid stimulus
- response to estradiol stimulus
- cellular response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding