GPR182 Gene Summary [Human]
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GPR182 |
| Official Name | G protein-coupled receptor 182 [Source:HGNC Symbol;Acc:HGNC:13708] |
| Ensembl ID | ENSG00000166856 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 182 |
| Synonyms | 7TMR, ADMR, Adrenomedullin Receptor, AM-R, G10-D, gamrh, Gpcr17, Gpcr22, G protein-coupled receptor 182, hrhAMR, L1, L1-R, L1 Receptor, MB10, NOW |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR182 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- adrenomedullin receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the GPR182 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
role in cell
- proliferation
- number
- morphology
- invasiveness
- Clathrin mediated endocytosis by
- autophagy in
- colony formation ability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR182 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- transmembrane signaling receptor activity