STAU1 Gene Summary [Human]
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]
Details
| Type | Protein Coding |
| Official Symbol | STAU1 |
| Official Name | staufen double-stranded RNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11370] |
| Ensembl ID | ENSG00000124214 |
| Bio databases IDs | |
| Aliases | staufen double-stranded RNA binding protein 1, protein phosphatase 1, regulatory subunit 150 |
| Synonyms | 5830401L18Rik, PPP1R150, STAU, Staufen, staufen double-stranded RNA binding protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STAU1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding domain
- protein phosphatase 1 binding
- Double-stranded RNA binding motif
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- protein binding
- dsRNA-binding domain
- Staufen C-terminal domain
- transporter
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- schizophrenia
- major depression
- insomnia
- Alzheimer disease
- infection by Dengue virus 2
role in cell
- proliferation
- expression in
- production in
- apoptosis
- growth
- formation
- localization in
- transport in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- polyribosome fractions
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- cytoplasmic ribonucleoprotein granule
- perinuclear region
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- microtubules
- microtubule bundles
- granules
- cytosol
- nucleoli
- neurofilaments
- neurites
- rough endoplasmatic reticulum
- actin stress fibers
- stress granule
- membrane processes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STAU1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- intracellular mRNA localization
- positive regulation of long-term synaptic potentiation
- cellular response to oxidative stress
- protein localization to synapse
- positive regulation of viral genome replication
- positive regulation of viral protein levels in host cell
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- rough endoplasmic reticulum
- endoplasmic reticulum
- neuronal cell body
- neuron projection
- plasma membrane
- microtubule associated complex
- dendrite
- extracellular vesicular exosome
- cytoplasm
- membrane
- cell body
- dendrite cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- double-stranded RNA binding
- mRNA binding
- protein phosphatase 1 binding