ANGPTL1 Gene Summary [Human]
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ANGPTL1 |
| Official Name | angiopoietin like 1 [Source:HGNC Symbol;Acc:HGNC:489] |
| Ensembl ID | ENSG00000116194 |
| Bio databases IDs | |
| Aliases | angiopoietin like 1, angioarrestin |
| Synonyms | 2810039D03Rik, ANG3, Angiopoietin3, angiopoietin-like 1, ANGPT3, ANGY, ARP1, dJ595C2.2, LOC684489, UNQ162 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANGPTL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fibrinogen-like domain
- signal peptide
- linker domain
- coiled-coil domain
- receptor binding
- FReD
- PB1
Pathways
Biological processes and signaling networks where the ANGPTL1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- heparin
- TEK
disease
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- atherosclerosis
- colorectal cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- hemangioma
- angiomatosis
- aldosterone producing adrenocortical adenoma
role in cell
- migration
- apoptosis
- proliferation
- binding
- survival
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANGPTL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- receptor binding