CHUK Gene Summary [Human]
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CHUK |
| Official Name | component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] |
| Ensembl ID | ENSG00000213341 |
| Bio databases IDs | |
| Aliases | component of inhibitor of nuclear factor kappa B kinase complex, inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase |
| Synonyms | BPS2, Chuk1, Chuk predicted, component of inhibitor of nuclear factor kappa B kinase complex, component of inhibitor of nuclear factor κ B kinase complex, CONSERVED HELIX-LOOP-HELIX UBIQUITOUS KINASE, Fbx24, Fbxo24, ikappab kinase α, IKBKA, Ikb kinase 1, IkB Kinase Alpha, IkB Kinase α, IKK-1, IKKA, IKK[A], IKK-alpha, IKK-α, NFKBIKA, TCF16 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHUK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- I-kappa-kinase-beta NEMO binding domain
- protein serine/threonine kinase
- protein kinase
- IQBAL scaffold dimerization domain
- ATP-binding domain
- leucine zipper domain
- Protein kinase domain
- activation loop
- serine-rich region
- helix-loop-helix domain
- nuclear localization sequence
- protein binding
- receptor binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- PEST domain
- NEMO-binding domain
- binding protein
- Protein Kinases, catalytic domain
- Ubl1_cv_Nsp3_N-like
- protein homodimerization
- ikappaB kinase
- protein heterodimerization
Pathways
Biological processes and signaling networks where the CHUK gene in human plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- IL-17A Signaling in Airway Cells
- IL-6 Signaling
- Induction of Apoptosis by HIV1
- LPS-stimulated MAPK Signaling
- Lymphotoxin β Receptor Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- PEDF Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- atherosclerosis
- omphalocele
- inflammatory bowel disease
- hepatic fibrosis
- chronic renal impairment
- chronic kidney disease
- tumorigenesis
role in cell
- cell death
- apoptosis
- proliferation
- expression in
- motility
- invasiveness
- molecular cleavage in
- processing in
- phosphorylation in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- nuclear matrix fraction
- Nucleus
- Mitochondria
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
- nuclear speckles
- nuclear lamina
- membrane rafts
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHUK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- I-kappaB phosphorylation
- response to amino acid stimulus
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- anatomical structure morphogenesis
- response to xenobiotic stimulus
- response to virus
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of NF-kappaB transcription factor activity
- response to toxin
- positive regulation of interferon-alpha production
- inflammatory response
- striated muscle cell differentiation
- immune response
- skeletal muscle contraction
- positive regulation of transcription, DNA-dependent
- cellular response to cadmium ion
- cellular response to tumor necrosis factor
- response to acetate
- response to hydroperoxide
- negative regulation of NF-kappaB transcription factor activity
- toll-like receptor 4 signaling pathway
- NIK/NF-kappaB cascade
- Rho protein signal transduction
- I-kappaB kinase/NF-kappaB cascade
- tumor necrosis factor-mediated signaling pathway
- innate immune response
- response to lipopolysaccharide
- peptidyl-serine phosphorylation
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- IkappaB kinase complex
- cytoplasm
- cytosol
- CD40 receptor complex
- nucleoplasm
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- ATP binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- IkappaB kinase activity
- protein kinase activity
- protein serine/threonine kinase activity