Angptl1 Gene Summary [Mouse]
Enables signaling receptor binding activity. Acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; heart; intraembryonic coelom; limb mesenchyme; and skeleton. Orthologous to human ANGPTL1 (angiopoietin like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Angptl1 |
| Official Name | angiopoietin-like 1 [Source:MGI Symbol;Acc:MGI:1919963] |
| Ensembl ID | ENSMUSG00000033544 |
| Bio databases IDs | |
| Aliases | angiopoietin-like 1 |
| Synonyms | 2810039D03Rik, ANG3, Angiopoietin3, angiopoietin-like 1, ANGPT3, ANGY, ARP1, dJ595C2.2, LOC684489, UNQ162 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Angptl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fibrinogen-like domain
- signal peptide
- linker domain
- coiled-coil domain
- receptor binding
- FReD
- PB1
Pathways
Biological processes and signaling networks where the Angptl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- heparin
- TEK
disease
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- atherosclerosis
- colorectal cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- hemangioma
- angiomatosis
- aldosterone producing adrenocortical adenoma
role in cell
- migration
- apoptosis
- proliferation
- binding
- survival
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Angptl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- receptor binding