CLEC1B Gene Summary [Human]
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | CLEC1B |
| Official Name | C-type lectin domain family 1 member B [Source:HGNC Symbol;Acc:HGNC:24356] |
| Ensembl ID | ENSG00000165682 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 1 member B |
| Synonyms | 1810061I13Rik, CLEC2, CLEC2B, C-type lectin domain family 1 member B, C-type lectin domain family 1, member B, PRO1384, QDED721, RGD1563517 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hemITAM motif
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- rheumatoid arthritis
- epithelial neoplasia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- disease-specific survival
- deep vein thrombosis
- testicular seminoma
- seminomatous testicular cancer
role in cell
- formation
- expression in
- function
- proliferation
- migration
- secretion
- activation
- cell viability
- aggregation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- membrane surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- platelet formation
- cell surface receptor signaling pathway
- defense response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- carbohydrate binding