RCOR3 Gene Summary [Human]
Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RCOR3 |
| Official Name | REST corepressor 3 [Source:HGNC Symbol;Acc:HGNC:25594] |
| Ensembl ID | ENSG00000117625 |
| Bio databases IDs | |
| Aliases | REST corepressor 3 |
| Synonyms | 4921514E24Rik, C730034D20Rik, E130101E15Rik, KIAA1343, LOC102551140, REST corepressor 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RCOR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- ELM2 domain
- Myb-like DNA-binding domain
- enzyme binding
- protein binding
Pathways
Biological processes and signaling networks where the RCOR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- chromophobe renal cell carcinoma
regulated by
- tetrachlorodibenzodioxin
- Human herpesvirus 1 strain KOS
- 17-alpha-ethinylestradiol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RCOR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- histone deacetylase complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity