GATA2 Gene Summary [Human]
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | GATA2 |
| Official Name | GATA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4171] |
| Ensembl ID | ENSG00000179348 |
| Bio databases IDs | |
| Aliases | GATA binding protein 2 |
| Synonyms | DCML, GATA binding protein 2, IMD21, MGC2306, MONOMAC, NFE1B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GATA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- transcription factor binding
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- carboxy finger domain
- zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- zinc finger domain
- transcription factor activity
- ZnF_GATA
- amino finger domain
Pathways
Biological processes and signaling networks where the GATA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- anemia
- acute myeloid leukemia associated with myelodysplastic syndrome
- monocytopenia and mycobacterial infection syndrome
- acute myeloid leukemia
- androgenic alopecia
- primary lymphedema with myelodysplasia
- GATA2-related disorder
- hereditary disorder
role in cell
- expression in
- cell viability
- number
- activity
- quantity
- activation in
- apoptosis
- proliferation
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GATA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mast cell degranulation
- thyroid-stimulating hormone-secreting cell differentiation
- transcription from RNA polymerase II promoter
- fat cell differentiation
- ventral spinal cord interneuron differentiation
- central nervous system neuron development
- positive regulation of cell migration involved in sprouting angiogenesis
- positive regulation of erythrocyte differentiation
- positive regulation of angiogenesis
- hemopoietic progenitor cell differentiation
- brown fat cell differentiation
- neuroblast proliferation
- negative regulation of neuroblast proliferation
- negative regulation of macrophage differentiation
- negative regulation of endothelial cell apoptotic process
- cell fate determination
- semicircular canal development
- cochlea development
- vascular wound healing
- commitment of neuronal cell to specific neuron type in forebrain
- positive regulation of megakaryocyte differentiation
- negative regulation of gene expression
- positive regulation of gene expression
- inner ear morphogenesis
- positive regulation of phagocytosis
- positive regulation of phagocytosis, engulfment
- cell differentiation in hindbrain
- positive regulation of neuron differentiation
- neuron maturation
- negative regulation of Notch signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- embryonic placenta development
- negative regulation of transcription from RNA polymerase II promoter
- neuron migration
- regulation of forebrain neuron differentiation
- somatic stem cell maintenance
- negative regulation of neural precursor cell proliferation
- response to lipid
- eosinophil fate commitment
- glandular epithelial cell maturation
- positive regulation of blood vessel endothelial cell migration
- elevation of cytosolic calcium ion concentration
- definitive hemopoiesis
- GABAergic neuron differentiation
- urogenital system development
- regulation of primitive erythrocyte differentiation
- homeostasis of number of cells within a tissue
- cell fate commitment
- phagocytosis
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor binding
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- C2H2 zinc finger domain binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- transcription coactivator binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity