MID2 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | MID2 |
| Official Name | midline 2 [Source:HGNC Symbol;Acc:HGNC:7096] |
| Ensembl ID | ENSG00000080561 |
| Bio databases IDs | |
| Aliases | midline 2 |
| Synonyms | FXY2, LOC286440, Midin 2, midline 2, Midline defect 2, MRX101, RGD1565674, RNF60, TRIM1, XLID101 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MID2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- transcription co-activator
- B-Box C-terminal domain
- SPRY domain
- zinc finger of C3HC4-type, RING
- phosphoprotein binding
- enzyme binding
- Purple acid Phosphatase, N-terminal domain
- TRIM C-terminal subgroup One Signature domain
- enzyme
- Ring finger domain
- protein binding
- Fibronectin type 3 domain
- identical protein binding
- microtubule binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- FN3
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein homodimerization
- B-box zinc finger
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked mental retardation
- Turner syndrome
- X-linked mental retardation type 101
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
role in cell
- expression in
- activation in
- cell death
- autophagy by
- neurite outgrowth in
- innate immune response in
- ubiquitination in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MID2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- positive regulation of transcription, DNA-dependent
- negative regulation of viral entry into host cell
- protein localization to microtubule
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of viral transcription
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein homodimerization activity
- transcription coactivator activity
- phosphoprotein binding
- transferase activity
- enzyme binding
- microtubule binding