KBTBD7 Gene Summary [Human]
The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | KBTBD7 |
| Official Name | kelch repeat and BTB domain containing 7 [Source:HGNC Symbol;Acc:HGNC:25266] |
| Ensembl ID | ENSG00000120696 |
| Bio databases IDs | |
| Aliases | kelch repeat and BTB domain containing 7 |
| Synonyms | 1110008P08RIK, BAIP2, Gm295, kelch repeat and BTB domain containing 7, kelch repeat and BTB (POZ) domain containing 7, LOC100912730, LOC103693883 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KBTBD7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KBTBD7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of signal transduction
- protein K48-linked ubiquitination
- regulation of Rac protein signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding