PIGT Gene Summary [Human]
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | PIGT |
| Official Name | phosphatidylinositol glycan anchor biosynthesis class T [Source:HGNC Symbol;Acc:HGNC:14938] |
| Ensembl ID | ENSG00000124155 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis class T, GPI transamidase subunit |
| Synonyms | 2510012P17RIK, 4930534E15Rik, CGI-06, GPI AMIDASE, MCAHS3, NDAP, Ndap7, phosphatidylinositol glycan anchor biosynthesis class T, phosphatidylinositol glycan anchor biosynthesis, class T, PNH2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIGT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- binding protein
- Gpi16 subunit, GPI transamidase component
- lumenal domain
- transmembrane domain
- protein binding
- cytosolic tail domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- multiple congenital anomalies-hypotonia-seizures syndrome type 3
- hereditary disorder
- breast carcinoma
- susceptibility to paroxysmal nocturnal hemoglobinuria type 2
- epilepsy
- bladder cancer
- paroxysmal nocturnal hemoglobinuria type 2
role in cell
- proliferation
- apoptosis
- expression in
- differentiation
- glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIGT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- attachment of GPI anchor to protein
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- cytoplasmic vesicle
- GPI-anchor transamidase complex
Molecular Function
What the gene product does at the molecular level
- protein binding