ABCC4 Gene Summary [Human]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | ABCC4 |
| Official Name | ATP binding cassette subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:55] |
| Ensembl ID | ENSG00000125257 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily C member 4, canalicular multispecific organic anion transporter (ABC superfamily), bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4), multidrug resistance-associated protein 4, multispecific organic anion transporter B |
| Synonyms | ABCC4-N1, ATP binding cassette subfamily C member 4, ATP-binding cassette, sub-family C member 4, ATP binding cassette subfamily C member 4 (PEL blood group), D630049P08Rik, MOAT-B, MRP4, RGD1565953 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ABCC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- efflux permease
- conjugate transporter
- urate transporter
- heme ABC exporter, ATP-binding protein CcmA
- purine nucleotide transporter
- thiol reductant ABC exporter, CydC subunit
- tail domain
- multi drug resistance-associated protein (MRP)
- bile acid porter
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- PDZ domain ligand
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- protein binding
- organic anion transporter
- inorganic anion transporter
- tripeptide transporter
- prostaglandin transporter
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- thiol reductant ABC exporter, CydD subunit
- organic alcohol transporter
- cystic fibrosis transmembrane conductor regulator (CFTR)
- xenobiotic transporter
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- transporter
Pathways
Biological processes and signaling networks where the ABCC4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- prostate cancer
- prostatic intraepithelial neoplasia
- prostatic neoplasia
- colorectal cancer
- weight loss
- colitis
- breast carcinoma
regulates
- methotrexate
- Collagen type I (complex)
- GLI1
- cyclic AMP
- cyclic GMP
- adefovir
- Sult2a1 (includes others)
- testosterone
- 17beta-estradiol-17-beta-D-glucuronide
- topotecan
role in cell
- aggregation
- phosphorylation in
- expression in
- migration
- production in
- growth
- cell death
- proliferation
- differentiation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- basal compartment
- cellular membrane
- Nucleus
- Golgi Apparatus
- secretory granule membrane
- plasma membrane extracellular face
- apical membrane
- basolateral membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ABCC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene transport
- transmembrane transport
- cilium morphogenesis
- platelet degranulation
- drug transmembrane transport
- xenobiotic metabolic process
- glutathione transmembrane transport
- urate transport
- cAMP transport
- prostaglandin secretion
- prostaglandin transport
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- membrane
- platelet dense granule membrane
- Golgi apparatus
- nucleolus
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- xenobiotic transporter activity
- 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
- ATPase activity, coupled to transmembrane movement of substances
- bile acid-exporting ATPase activity
- glutathione S-conjugate-exporting ATPase activity
- efflux transmembrane transporter activity
- urate transmembrane transporter activity
- prostaglandin transmembrane transporter activity
- guanine nucleotide transmembrane transporter activity
- xenobiotic-transporting ATPase activity
- anion transmembrane-transporting ATPase activity
- ATP binding
- protein binding
- purine nucleotide transmembrane transporter activity
- glutathione transmembrane transporter activity