NPBWR2 Gene Summary [Human]
The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NPBWR2 |
| Official Name | neuropeptides B and W receptor 2 [Source:HGNC Symbol;Acc:HGNC:4530] |
| Ensembl ID | ENSG00000125522 |
| Bio databases IDs | |
| Aliases | neuropeptides B and W receptor 2 |
| Synonyms | Gm14489, GPR8, neuropeptides B and W receptor 2, neuropeptides B/W receptor 2 pseudogene |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPBWR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- opioid receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the NPBWR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPBWR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- opioid receptor signaling pathway
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- opioid receptor activity
- G-protein coupled receptor activity
- neuropeptide binding
- protein binding
- neuropeptide receptor activity