PSMA3 Gene Summary [Human]
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PSMA3 |
| Official Name | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] |
| Ensembl ID | ENSG00000100567 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit alpha 3, proteasome subunit α7 |
| Synonyms | 20S PROTEASOME alpha 3 subunit, 20S PROTEASOME α 3 subunit, C8, HC8, Lmpc8, PRC8, proteasome 20S subunit alpha 3, proteasome 20S subunit α 3, proteasome subunit alpha 3, PROTEASOME subunit alpha type 3, proteasome subunit α 3, PROTEASOME subunit α type 3, PSC3, Psma3l |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- ubiquitin protein ligase binding
- proteasome endopeptidase complex
- Proteasome subunit A N-terminal signature
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the PSMA3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- digenic proteasome-associated autoinflammatory syndrome 1
- psoriasis
- proximal tubular toxicity
- non-small cell lung cancer
- cold thyroid nodule
- infection by HIV-1
regulates
role in cell
- production in
- cell death
- cell viability
- JQ1-sensitivity
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- synapse
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- proteasome core complex, alpha-subunit complex
- cytosol
- proteasome complex
- synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding