EML2 Gene Summary [Human]
Enables microtubule binding activity. Involved in negative regulation of microtubule polymerization and regulation of microtubule nucleation. Colocalizes with mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EML2 |
| Official Name | EMAP like 2 [Source:HGNC Symbol;Acc:HGNC:18035] |
| Ensembl ID | ENSG00000125746 |
| Bio databases IDs | |
| Aliases | EMAP like 2, echinoderm MT-associated protein (EMAP)-like protein 70, microtubule-associated protein like echinoderm EMAP |
| Synonyms | 1600029N02RIK, echinoderm microtubule associated protein like 2, ELP70, EMAP, EMAP-2, EMAP like 2, Eml1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EML2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- WD40 repeats
- tubulin binding
- HELP motif
- TD_EMAP-like
- WD40
- protein binding
- ionotropic glutamate receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- mitotic spindle
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EML2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- regulation of microtubule nucleation
- microtubule cytoskeleton organization
- visual perception
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- cytoplasm
- microtubule associated complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- microtubule binding