CEBPB Gene Summary [Human]
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Details
| Type | Protein Coding |
| Official Symbol | CEBPB |
| Official Name | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] |
| Ensembl ID | ENSG00000172216 |
| Bio databases IDs | |
| Aliases | CCAAT enhancer binding protein beta, liver-enriched transcriptional activator protein, nuclear factor of interleukin 6, interleukin 6-dependent DNA-binding protein |
| Synonyms | Agp/eb, ANF-1, ANF-2, CCAAT enhancer binding protein beta, CCAAT/enhancer binding protein beta, CCAAT enhancer-binding protein β, CCAAT/enhancer binding protein β, C/EBP-beta, C/Ebp Beta-Lip, C/EBP-β, Cebp β, C/Ebp β-Lip, CRP2, IL-6DBP, NF-IL6, NF-M, TCF5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEBPB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RD rich domain
- transcription regulator
- regulatory domain
- transcription activation domain
- transcription factor binding
- leucine zipper domain
- chromatin binding
- CR domain
- identical protein binding
- proline rich domain
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- ERK/GSK3 phosphorylation site
- bZIP
- histone acetyltransferase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- ligand-dependent nuclear receptor interactor
- acetylation site
- dimerization domain
- MAPK phosphorylation site
- DNA binding domain
- nucleic acid binding
- GSK3 beta phosphorylation site
- CR1 domain
- nuclear localization sequence
- enzyme binding
- Basic region leucine zipper
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- kinase binding
- basic amino acid motif
- double-stranded DNA binding
- protein homodimerization
- ERK phosphorylation site
- GCN5 binding domain
- protein heterodimerization
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the CEBPB gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Adipogenesis pathway
- Adrenomedullin signaling pathway
- DNA Methylation and Transcriptional Repression Signaling
- IL-12 Signaling and Production in Macrophages
- IL-17 Signaling
- IL-17A Signaling in Fibroblasts
- IL-6 Signaling
- JAK/Stat Signaling
- Osteoarthritis Pathway
- Prolactin Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Type II Diabetes Mellitus Signaling
- Unfolded protein response
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- esophageal squamous cell carcinoma
- infection
- rheumatoid arthritis
- asthma
- obesity
- Alzheimer disease
- memory deficits
- epithelial cancer
role in cell
- invasion by
- expression in
- proliferation
- growth
- recruitment in
- activation in
- migration
- phosphorylation in
- survival
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nuclear envelope
- nuclear matrix
- centromeres
- chromatin
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEBPB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic cell differentiation
- positive regulation of sodium-dependent phosphate transport
- positive regulation of fat cell differentiation
- transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- mammary gland epithelial cell differentiation
- embryonic placenta development
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- brown fat cell differentiation
- cellular response to amino acid stimulus
- inflammatory response
- immune response
- regulation of cell differentiation
- positive regulation of transcription, DNA-dependent
- regulation of osteoclast differentiation
- mammary gland epithelial cell proliferation
- positive regulation of biomineral tissue development
- neuron differentiation
- positive regulation of inflammatory response
- regulation of transcription, DNA-dependent
- acute-phase response
- defense response to bacterium
- regulation of transcription from RNA polymerase II promoter
- ovarian follicle development
- negative regulation of T cell proliferation
- hepatocyte proliferation
- regulation of interleukin-6 production
- response to lipopolysaccharide
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- positive regulation of interleukin-4 production
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- condensed chromosome, centromeric region
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- histone acetyltransferase binding
- protein homodimerization activity
- histone deacetylase binding
- RNA polymerase II core promoter sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- small conjugating protein ligase binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- kinase binding