TRAP1 Gene Summary [Human]
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TRAP1 |
| Official Name | TNF receptor associated protein 1 [Source:HGNC Symbol;Acc:HGNC:16264] |
| Ensembl ID | ENSG00000126602 |
| Bio databases IDs | |
| Aliases | TNF receptor associated protein 1 |
| Synonyms | 2410002K23RIK, HSP 75, HSP90L, TNF receptor-associated protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- Hsp90 protein
- protein kinase binding
- Histidine kinase-like ATPase domain
- PRK05218
- enzyme
- protein binding
- LXCXE binding site
- Histidine kinase-like ATPases
- RNA binding
Pathways
Biological processes and signaling networks where the TRAP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- tumorigenesis
- colorectal carcinoma
- colorectal carcinomagenesis
- limited systemic sclerosis
- congenital anomalies of kidney and urinary tract
- colon cancer
- hyperplasia
- nonsyndromic renal hypodysplasia 1
- gout
role in cell
- expression in
- proliferation
- apoptosis
- production in
- induction in
- growth
- mitochondrial respiration in
- tumorigenicity
- invasion by
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational attenuation
- chaperone-mediated protein folding
- protein folding
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial matrix
- membrane
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
- cell periphery
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein kinase binding
- ATP binding
- RNA binding
- protein binding
- tumor necrosis factor receptor binding
- unfolded protein binding