HSPA9 Gene Summary [Human]
This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | HSPA9 |
| Official Name | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] |
| Ensembl ID | ENSG00000113013 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 9, mortalin2, mortalin, 75 kDa glucose-regulated protein, Stress-70 protein, mitochondrial |
| Synonyms | Crp40, CSA, EVPLS, GRP-75, heat shock protein 9, heat shock protein family A (Hsp70) member 9, HEL-S-124m, Hsc74, HSP74, Hsp74a, Hspa9a, HSPA9B, IDBP-3, LOC100912578, Mitochondrial stress-70, Mortalin, MOT, MOT2, MTHSP70, MTHSP75, PBP74, SAAN, SIDBA4, Stress-70 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSPA9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- MreB/Mbl protein
- Cell division protein FtsA
- heat shock protein binding
- enzyme binding
- peptide-binding domain
- protein binding
- ATPase
- Fe-S protein assembly chaperone HscA
- fibroblast growth factor binding
- ATPase domain
- chaperone protein DnaK
- chaperone binding
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HSPA9 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Aldosterone Signaling in Epithelial Cells
- eNOS Signaling
- Glucocorticoid Receptor Signaling
- HIF1α Signaling
- Huntington's Disease Signaling
- Iron homeostasis signaling pathway
- Natural Killer Cell Signaling
- Protein Ubiquitination Pathway
- Role of PKR in Interferon Induction and Antiviral Response
- Unfolded protein response
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- hepatitis B surface antigen-negative hepatitis C virus negative hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hereditary sideroblastic anemia
- hepatocellular carcinoma
- autosomal dominant sideroblastic anemia
- EVEN-plus syndrome
- esophagus neoplasm
role in cell
- growth
- survival
- expression in
- apoptosis
- activation in
- invasion by
- cell cycle progression
- cell death
- production in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- extranuclear space
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- centrosome
- Mitochondria
- mitochondria-associated membranes
- mitochondrial matrix
- mitochondrial nucleoids
- mitochondrial inner membrane
- inner nuclear membrane
- nucleoli
- nuclear envelope
- acrosome
- cytoplasmic vesicles
- endocytotic vesicle
- microsomal membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSPA9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- negative regulation of apoptotic process
- chaperone mediated protein folding requiring cofactor
- negative regulation of erythrocyte differentiation
- intracellular protein transport
- inner mitochondrial membrane organization
- protein refolding
- protein export from nucleus
- iron-sulfur cluster assembly
- regulation of erythrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial inner membrane presequence translocase complex
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- mitochondrial matrix
- mitochondrion
- nucleolus
- mitochondrial sorting and assembly machinery complex
- mitochondrial inner membrane
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- heat shock protein binding
- protein binding
- ubiquitin protein ligase binding
- protein binding involved in protein folding
- RNA binding
- unfolded protein binding