PLPPR3 Gene Summary [Human]
The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PLPPR3 |
| Official Name | phospholipid phosphatase related 3 [Source:HGNC Symbol;Acc:HGNC:23497] |
| Ensembl ID | ENSG00000129951 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase related 3 |
| Synonyms | LOC100363739, LPPR3, LPR3, phospholipid phosphatase related 3, PRG-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLPPR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- PAP2 superfamily
- phosphatidate phosphatase
- phosphatase
- protein binding
- PAP2_like
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLPPR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- signal transduction
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity