HTR3A Gene Summary [Human]
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HTR3A |
| Official Name | 5-hydroxytryptamine receptor 3A [Source:HGNC Symbol;Acc:HGNC:5297] |
| Ensembl ID | ENSG00000166736 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine receptor 3A |
| Synonyms | 5-HT-3, 5-HT3A, 5-HT3R, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine (serotonin) receptor 3A, HTR3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTR3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intracellular loop
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- serotonin binding
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- identical protein binding
- ion channel
- LGIC_ECD
- neurotransmitter receptor
- Neurotransmitter-gated ion-channel transmembrane region
- ligand-binding domain
- Neurotransmitter-gated ion-channel ligand binding domain
- transmembrane domain
- ligand-gated ion channel
- intracellular domain
- loop domain
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the HTR3A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- infection
- plasma cell myeloma
- bacterial disease
- sepsis
- Sézary syndrome
- diarrhea
- obesity
- mycosis fungoides
- viral disease
role in cell
- activation
- loss
- proliferation
- function
- complexity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- cleavage furrow
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTR3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- regulation of membrane potential
- ion transmembrane transport
- synaptic transmission
- serotonin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- cleavage furrow
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- identical protein binding
- protein binding
- excitatory extracellular ligand-gated ion channel activity
- serotonin-gated cation channel activity