SYT5 Gene Summary [Human]
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | SYT5 |
| Official Name | synaptotagmin 5 [Source:HGNC Symbol;Acc:HGNC:11513] |
| Ensembl ID | ENSG00000129990 |
| Bio databases IDs | |
| Aliases | synaptotagmin 5 |
| Synonyms | SYNAPTOTAGMIN 5, synaptotagmin V, SytIX, SytV |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYT5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- phospholipid binding
- N-terminal domain of synaptotagmin-1 and -2
- calcium ion binding
- clathrin binding
- calcium-dependent phospholipid binding
- syntaxin binding
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- Protein kinase C conserved region 2 (CalB)
- protein heterodimerization
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the SYT5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- secretory granule membrane
- synaptic membrane
- synaptic vesicles
- neurites
- dense-core vesicles
- synaptic-like microvesicles
- secretory granules
- perikaryon
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYT5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion-dependent exocytosis of neurotransmitter
- synaptic vesicle endocytosis
- synaptic transmission
- regulation of calcium ion-dependent exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- perinuclear region of cytoplasm
- recycling endosome membrane
- neuronal cell body
- dense core granule
- synaptic vesicle membrane
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- syntaxin binding
- protein heterodimerization activity
- calcium ion binding
- clathrin binding
- SNARE binding
- calcium-dependent phospholipid binding