Syt5 Gene Summary [Mouse]
Enables SNARE binding activity; phospholipid binding activity; and protein heterodimerization activity. Involved in regulation of calcium ion-dependent exocytosis. Located in several cellular components, including dense core granule; neuronal cell body; and proximal neuron projection. Is active in neuronal dense core vesicle membrane. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human SYT5 (synaptotagmin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syt5 |
| Official Name | synaptotagmin V [Source:MGI Symbol;Acc:MGI:1926368] |
| Ensembl ID | ENSMUSG00000004961 |
| Bio databases IDs | |
| Aliases | synaptotagmin V |
| Synonyms | SYNAPTOTAGMIN 5, synaptotagmin V, SytIX, SytV |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- phospholipid binding
- N-terminal domain of synaptotagmin-1 and -2
- calcium ion binding
- clathrin binding
- calcium-dependent phospholipid binding
- syntaxin binding
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- Protein kinase C conserved region 2 (CalB)
- protein heterodimerization
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Syt5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- secretory granule membrane
- synaptic membrane
- synaptic vesicles
- neurites
- dense-core vesicles
- synaptic-like microvesicles
- secretory granules
- perikaryon
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion-dependent exocytosis of neurotransmitter
- synaptic vesicle endocytosis
- synaptic transmission
- regulation of calcium ion-dependent exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- perinuclear region of cytoplasm
- recycling endosome membrane
- neuronal cell body
- dense core granule
- synaptic vesicle membrane
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- syntaxin binding
- protein heterodimerization activity
- calcium ion binding
- clathrin binding
- SNARE binding
- calcium-dependent phospholipid binding