DEFB118
DEFB118 Gene Summary
This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity against E. coli. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | DEFB118 |
| Official Name | defensin beta 118 [Source:HGNC Symbol;Acc:HGNC:16196] |
| Ensembl ID | ENSG00000131068 |
| Bio databases IDs | |
| Aliases | defensin beta 118 |
| Synonyms | C20orf63,DEFB-18,Defb21,defensin beta 118,defensin beta 21,defensin β 118,defensin β 21,ESC42,ESP13.6 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
- protein binding
- lipopolysaccharide binding
Pathways
Biological processes and signaling networks where the DEFB118 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- IFI30
- GUCA1A
- THOP1
disease
- insomnia
regulated by
regulates
role in cell
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the DEFB118 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell-matrix adhesion
- defense response to Gram-negative bacterium
- innate immune response
- negative regulation of cell adhesion
- spermatogenesis
- killing of cells of other organism
- defense response to bacterium
- defense response to Gram-positive bacterium
- negative regulation of lipopolysaccharide-mediated signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- lipopolysaccharide binding